Cellular Resilience denotes the inherent ability of individual cells to withstand or quickly recover from endogenous insults, such as oxidative stress or metabolic fluctuations, while maintaining functional integrity. This is a microscopic foundation for whole-body adaptability.
Origin
The term merges the structural unit of life, the cell, with the concept of resilience, borrowed from material science to describe resistance to physical or chemical change. In physiology, it pertains to molecular maintenance pathways.
Mechanism
This process relies heavily on the cell’s capacity to upregulate protective chaperones, manage reactive oxygen species via mitochondrial regulation, and efficiently repair DNA damage. Hormonal signaling, particularly through nuclear receptor activation, often dictates the transcription of genes governing these essential survival pathways.
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