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Cellular Resensitization

Meaning

Cellular Resensitization is the physiological process of restoring a cell’s diminished responsiveness to a signaling molecule, such as a hormone or neurotransmitter, following a period of chronic overstimulation or desensitization. This adaptive mechanism is crucial for maintaining proper endocrine function, particularly when target cells exhibit reduced receptor density or impaired post-receptor signaling pathways. Clinical interventions in hormonal health often aim to induce resensitization to improve the efficacy of endogenous or administered hormones.