These are clinical and lifestyle interventions aimed at activating and enhancing the body’s intrinsic molecular and cellular processes for damage correction and structural maintenance. Strategies focus on optimizing mechanisms like DNA repair, mitochondrial biogenesis, and autophagy to counteract age-related decline and cellular senescence. The goal is to improve tissue function and extend healthspan by preserving cellular integrity. These protocols are essential for maintaining the body’s functional reserve over time.
Origin
The concept is rooted in molecular biology and gerontology, recognizing that accumulated cellular damage is a primary driver of aging and disease. Modern strategies evolved from basic research into stress response pathways and nutrient sensing mechanisms, such as the mTOR and AMPK pathways. This translational approach moves laboratory discoveries into clinical protocols for regenerative health.
Mechanism
Cellular repair strategies operate by stimulating endogenous repair pathways often suppressed by chronic nutrient excess or inflammation. Interventions like intermittent fasting can activate autophagy, a crucial cellular self-cleaning process that removes damaged organelles and misfolded proteins. Furthermore, optimizing hormone levels, such as growth hormone and DHEA, can support DNA repair enzyme activity and reduce oxidative stress. This comprehensive support facilitates robust cellular maintenance and tissue renewal.
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