What is the Origin of Cellular Repair Signalling?

Signalling refers to the transmission of information between cells, while repair denotes the action of restoring integrity. In a hormonal context, this process is heavily modulated by systemic factors that indicate the body's overall state of resource availability and stress. The origin lies in understanding how cells communicate damage status to the regulatory centers.

What is the Mechanism of Cellular Repair Signalling?

Damage often triggers the release of local mediators or systemic signals, such as specific growth factors or modulatory peptides, which bind to surface receptors. This binding initiates intracellular kinase cascades, ultimately leading to the activation of transcription factors that upregulate repair enzymes and chaperone proteins. Effective signalling prevents accumulation of molecular damage that could otherwise lead to functional decline or senescence.

Cellular Repair Signalling

Meaning

The complex network of molecular communications that initiates and coordinates the restorative processes following cellular damage or routine wear and tear. This signalling ensures the timely activation of DNA repair mechanisms, protein quality control, and the removal of senescent cells. It is a crucial determinant of cellular resilience.