Cellular Repair Signaling encompasses the intricate network of biochemical messages that initiate and coordinate the response to cellular stress, damage, or oxidative insult within tissues. This signaling cascade dictates whether a cell enters a repair state, senescence, or programmed cell death. It is a crucial determinant of tissue longevity and function.
Origin
The term arises from molecular biology, specifically the study of signal transduction pathways involved in DNA damage response and stress adaptation. It describes the communication necessary to restore cellular equilibrium following perturbation. This field directly intersects with endocrinology through hormone-mediated feedback loops.
Mechanism
Key pathways involve the activation of stress-response proteins like Heat Shock Proteins (HSPs) and the modulation of pathways like AMPK, which signals low energy states requiring resource reallocation. Hormones such as DHEA can influence the efficiency of these repair mechanisms by modulating inflammation. Successful signaling ensures that damaged components are removed and replaced effectively.
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