A targeted clinical approach to maximizing the inherent biological processes responsible for the detection, removal, and replacement of damaged cellular components, organelles, and macromolecules. This optimization is crucial for maintaining tissue integrity, preventing the accumulation of senescent cells, and ultimately slowing the physiological rate of aging. It directly supports longevity and sustained organ function.
Origin
This term is derived from molecular biology and gerontology, combining “cellular repair,” which encompasses processes like autophagy and DNA repair, with “optimization,” indicating the maximal efficiency of these systems. It highlights the body’s intrinsic maintenance mechanisms.
Mechanism
Optimization involves modulating key signaling pathways, such as mTOR and AMPK, which regulate the balance between cellular growth and catabolic recycling processes like autophagy. Growth factors and specific hormones, including Human Growth Hormone (HGH) and IGF-1, play a significant role in stimulating tissue regeneration and protein synthesis for repair. Reducing systemic oxidative stress also minimizes the initial damage burden that necessitates repair.
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