The measure of accuracy and precision with which cellular and molecular mechanisms execute the repair of damaged DNA, proteins, and organelles. High fidelity indicates that repair processes maintain the original, correct structure and function of the biological components, minimizing errors that lead to cellular senescence or mutation. This is a crucial determinant of tissue health, biological aging, and longevity.
Origin
The term combines “Cellular Repair,” a fundamental process in molecular biology and aging research, with “Fidelity,” a concept from information theory denoting faithfulness or accuracy of reproduction. Its clinical relevance lies in assessing the quality, not just the speed, of the body’s maintenance systems.
Mechanism
Fidelity relies on the complex interplay of DNA repair enzymes, chaperone proteins for protein folding, and the autophagy-lysosome system for clearing damaged organelles. Hormonal balance, particularly optimal growth hormone and thyroid status, supports the energetic requirements and regulatory signals for these repair pathways. Maintaining the structural integrity of telomeres is also a key component of this molecular precision.
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