The scientific discipline focused on reversing or slowing the hallmarks of cellular aging, aiming to restore cellular function closer to a younger physiological state. This involves targeting mechanisms such as telomere attrition, mitochondrial dysfunction, and accumulation of senescent cells. The goal is to improve tissue quality and extend the period of healthy function, known as healthspan.
Origin
This field draws heavily from molecular biology and gerontology, particularly research identifying the core drivers of aging at the cellular level. “Rejuvenation” speaks to the restorative ambition, while “Science” grounds the practice in empirical evidence derived from cell culture and animal models. It represents the cutting edge intersection of endocrinology and aging research.
Mechanism
Key mechanisms involve enhancing cellular quality control pathways, such as boosting proteostasis or autophagy, to clear accumulated damage. Strategies also focus on epigenetic reprogramming to reset the cellular methylation clock or utilizing senolytics to selectively eliminate senescent cells that secrete detrimental inflammatory factors. Ultimately, successful rejuvenation aims to improve the cell’s ability to respond appropriately to hormonal cues and environmental stress.
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