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Cellular Receptor Resistance

Meaning

Cellular Receptor Resistance is a clinical state characterized by a diminished or absent cellular response to a specific signaling molecule, such as a hormone, despite the presence of adequate or even supraphysiological concentrations of the ligand. This desensitization event compromises the downstream signal transduction cascade, leading to a functional impairment in the target tissue’s expected biological response. Understanding this resistance is crucial for diagnosing and treating core metabolic and endocrine disorders like insulin resistance, which severely impacts systemic homeostasis. The loss of cellular responsiveness necessitates a careful clinical approach to restore proper hormonal signaling.