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Cellular Quiescence Regulation

Meaning

Cellular Quiescence Regulation is the active biological process that controls a cell’s entry into and exit from the G0 state, a reversible non-proliferative state distinct from senescence or apoptosis. This regulatory mechanism is critical for tissue homeostasis, allowing stem and progenitor cells to conserve resources and protect their genomic integrity until they are needed for repair or regeneration. Effective regulation is essential for maintaining the regenerative capacity of tissues throughout the lifespan. Dysregulation of quiescence can lead to premature aging, exhaustion of stem cell pools, or uncontrolled proliferation.