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Cellular Programming Fidelity

Meaning

Cellular Programming Fidelity refers to the accuracy and integrity with which a cell maintains and executes its original genetic and epigenetic instructions throughout its lifespan. It represents the degree to which a cell’s phenotype, function, and regulatory networks remain true to its optimal, youthful blueprint. High fidelity ensures correct protein synthesis, appropriate gene expression, and proper cellular identity, which are all critical for tissue health and function. Loss of fidelity is a hallmark of aging and contributes significantly to cellular senescence and disease pathology.