A collection of measurable biomarkers and functional metrics used to assess the overall health, efficiency, and metabolic capacity of individual cells and cellular populations. These parameters extend beyond traditional clinical bloodwork to include indices of mitochondrial function, oxidative stress load, and telomere length. Optimizing these parameters is central to longevity and high-level physiological function, reflecting true biological age rather than chronological age.
Origin
This term is a convergence of molecular biology, clinical diagnostics, and the emerging field of precision health. It moves the focus of clinical assessment from organ-level function to the foundational “Cellular” level, with “Performance” denoting measurable output and efficiency.
Mechanism
The parameters quantify key cellular processes, such as the efficiency of ATP production via mitochondrial respiration and the integrity of DNA repair mechanisms. For instance, high cellular ATP output and low reactive oxygen species generation are indicative of robust performance. Hormones often serve as key regulators of these parameters, influencing mitochondrial biogenesis and anti-oxidant enzyme expression, thereby modulating cellular efficiency.
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