The intricate network of signaling molecules and receptors that facilitate communication within and between cells. These systems are fundamental to coordinating physiological responses, including those governed by the endocrine system. They ensure that hormonal signals received by a target cell are accurately translated into specific intracellular actions, regulating everything from gene expression to metabolic activity.
Origin
The concept stems from foundational cell biology and endocrinology, where “cellular” refers to the cell as the unit of action, and “messenger systems” describes the transmission of information via signal transduction pathways. This terminology emerged as scientists elucidated how hormones, the body’s primary messengers, elicit effects after binding to their specific cellular receptors.
Mechanism
A hormone, acting as the first messenger, binds to a receptor on the cell surface or inside the cell. This binding event initiates a cascade of intracellular events, often involving secondary messengers like cyclic AMP or calcium ions. These secondary messengers amplify the initial signal, ultimately leading to a change in cellular function, such as enzyme activation, protein synthesis, or the release of another hormone. This precise, multi-step process allows for finely tuned control over human physiology.
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