A set of structured clinical and lifestyle interventions specifically designed to modulate fundamental cellular processes that govern the lifespan and functional health of individual cells. These protocols aim to delay cellular senescence, enhance DNA repair mechanisms, and improve mitochondrial efficiency. The ultimate objective is to extend the healthspan of tissues and organs, thereby promoting systemic longevity.
Origin
This term is rooted in the burgeoning field of geroscience, which views aging as a treatable condition driven by specific cellular and molecular hallmarks. The development of “protocols” reflects the clinical translation of laboratory findings into actionable, repeatable therapeutic strategies. This approach often incorporates principles of nutritional and hormonal signaling.
Mechanism
Protocols frequently target sirtuin activity, which is involved in DNA repair and metabolic regulation, and mTOR signaling, a key pathway controlling cell growth and autophagy. Interventions may include caloric restriction mimetics or specific compounds that enhance mitochondrial biogenesis and reduce oxidative stress. Optimizing hormonal signaling, particularly growth hormone and insulin sensitivity, is also integral to maintaining youthful cellular function.
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