What is the Origin of Cellular Longevity Factors?

The concept is foundational to the modern field of biogerontology, stemming from discoveries in molecular biology that elucidated the core processes of cellular aging, or senescence. Research on caloric restriction and genetic pathways in model organisms established the existence of conserved pathways that influence lifespan. Clinical application focuses on identifying and therapeutically modulating these fundamental biological levers.

What is the Mechanism of Cellular Longevity Factors?

The primary mechanism involves regulating the cellular stress response and maintaining genomic stability. Sirtuins, for instance, are NAD+-dependent deacetylases that promote DNA repair and suppress inflammatory gene expression. Autophagy removes damaged organelles and proteins, preventing the accumulation of cellular debris that drives senescence. Hormonal balance, particularly the somatotropic axis, also indirectly influences these factors by supporting cellular turnover and repair.

Cellular Longevity Factors

Meaning

A collective term for the intrinsic molecular mechanisms and extrinsic modulators that govern the lifespan and functional integrity of individual cells within the human body. These factors include telomere maintenance, DNA repair enzymes, sirtuins, and the efficiency of the autophagy pathway. Their optimal function is directly correlated with tissue health, resilience, and systemic longevity.

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