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Cellular Instruction Integrity

Meaning

Cellular Instruction Integrity refers to the flawless transmission and execution of a biological signal—such as a hormone’s message—from its initial binding at the receptor down to the final genomic or non-genomic response within the cell. This concept underscores the quality and fidelity of cellular communication, which is crucial for maintaining tissue function and physiological homeostasis. Compromised integrity, often due to receptor desensitization or downstream signaling pathway defects, leads to functional hormone resistance and contributes to age-related decline. The clinical goal is to maintain or restore this integrity for optimal health.