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Cellular Downgrade

Meaning

Cellular Downgrade describes the progressive, deleterious reduction in the functional capacity and structural integrity of individual cells, often observed as a hallmark of biological aging and chronic pathology. This process is characterized by an accumulation of molecular damage, including mitochondrial dysfunction, telomere shortening, and impaired protein homeostasis. It signifies a retreat from optimal cellular performance, leading to reduced tissue and organ reserve capacity. Clinically, mitigating cellular downgrade is a primary objective in longevity and regenerative medicine protocols.