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Cellular Contract Expiration

Meaning

Cellular Contract Expiration is a metaphorical term used to describe the point at which a cell, typically due to cumulative stress or reaching its Hayflick limit, enters a state of irreversible growth arrest known as cellular senescence. This event signifies the end of the cell’s proliferative function and the onset of its transition into a senescent cell, which secretes pro-inflammatory factors. In the context of longevity, minimizing the expiration of these cellular contracts is a central goal for preserving tissue function and hormonal responsiveness. The accumulation of these cells contributes significantly to age-related decline and chronic disease pathogenesis.