The fundamental biological process encompassing the creation, assembly, and maintenance of the essential structures within a cell, including organelles like mitochondria, ribosomes, and the endoplasmic reticulum. This continuous renewal process is critical for cellular health, functional capacity, and the overall longevity of tissues and organs.
Origin
This concept is rooted in molecular and cellular biology, stemming from the understanding of cellular homeostasis and the dynamic turnover of intracellular structures, particularly through processes like mitochondrial biogenesis and protein synthesis. The term “genesis” emphasizes the creation and renewal aspect vital for vitality.
Mechanism
It is governed by complex signaling pathways, including those regulated by growth factors and specific hormones, which activate transcription factors like PGC-1alpha for mitochondrial biogenesis. These pathways initiate the transcription and translation of genetic information into new structural proteins and lipids, ensuring damaged or aging components are replaced to sustain peak cellular function.
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