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Cellular Communication Breakdown

Meaning

Cellular Communication Breakdown describes the pathological disruption of the intricate signaling networks that coordinate the functions of individual cells and tissues within an organism. This dysfunction can involve impaired hormone-receptor binding, faulty signal transduction pathways, or aberrant paracrine and autocrine messaging. Such a breakdown is a critical hallmark of aging and chronic disease, leading to a profound loss of tissue coordination and functional decline. This failure compromises the body’s ability to maintain systemic homeostasis.