What is the Origin of Cellular Apoptosis Resistance?

This concept originates from molecular biology and pathology, with apoptosis being the Greek term for "falling off," referring to the orderly demise of cells. Resistance describes the cell's ability to withstand the internal and external cues that typically initiate this process.

What is the Mechanism of Cellular Apoptosis Resistance?

Resistance is mediated by the expression and activity of anti-apoptotic proteins, such as the Bcl-2 family, which block the release of cytochrome c from the mitochondria. This action prevents the subsequent activation of caspases, the executioner enzymes of the apoptotic cascade. Hormonal factors and growth factors can also enhance cell survival signaling pathways, thereby contributing to the cell's ability to resist programmed death.

Cellular Apoptosis Resistance ∞ Area

Cellular Apoptosis Resistance

Meaning

Cellular Apoptosis Resistance describes the capacity of a cell to evade or suppress the programmed cell death pathways in response to intrinsic or extrinsic pro-apoptotic signals. In the context of longevity and tissue health, this resistance is a complex trait; while beneficial for healthy, functional cells under temporary stress, it can be detrimental when observed in senescent or damaged cells. Optimal wellness seeks a balance, promoting resistance in healthy tissue while facilitating the clearance of dysfunctional cells.