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Cellular Adaptation Thresholds

Meaning

Cellular Adaptation Thresholds define the maximum and minimum levels of stress or stimulation a cell can endure while still maintaining its homeostatic integrity and successfully implementing an adaptive response. Once a cell is pushed beyond its specific threshold, the adaptive mechanisms fail, leading instead to cellular damage, senescence, or apoptosis. These thresholds are dynamically influenced by genetic factors, nutrient availability, and the prevailing hormonal milieu. Understanding these limits is paramount for designing therapeutic interventions that promote beneficial hormesis without inducing cellular exhaustion.