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Cellular Adaptation Chronology

Meaning

The time-dependent sequence and rate at which individual cells and integrated tissue systems modify their gene expression, protein synthesis, and metabolic function in response to a sustained physiological stressor or therapeutic intervention. This chronology outlines the precise temporal framework required for a biological system to achieve a new, stable, and improved functional state, such as hypertrophy or enhanced insulin sensitivity. It underscores the non-instantaneous nature of biological change.