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CD38

Meaning

CD38 is a transmembrane glycoprotein that functions primarily as an enzyme, catalyzing the conversion of NAD+ to various calcium-mobilizing second messengers, including cyclic ADP-ribose. In the context of cellular and hormonal health, CD38 is recognized as a significant NAD+-consuming enzyme whose increased activity is linked to inflammation and age-related decline in cellular NAD+ levels. The depletion of NAD+ impairs sirtuin activity and mitochondrial function, thereby negatively impacting cellular energy and the precise signaling required for optimal endocrine function.