Skip to main content

Catechol-O-methyltransferase

Meaning

Catechol-O-methyltransferase (COMT) is a crucial enzyme involved in the metabolic breakdown of catecholamines, including dopamine, norepinephrine, and epinephrine, as well as catechol estrogens. This enzyme catalyzes the transfer of a methyl group to these compounds, effectively inactivating them and facilitating their excretion. The activity of COMT is highly significant in both neurotransmission and hormonal health, as genetic polymorphisms can lead to variations in the clearance rate of these important biological molecules. Understanding an individual’s COMT status is relevant for personalized hormone and neurotransmitter support.