What is the Origin of Catabolic Stress Response?

This concept is fundamental to metabolic physiology and endocrinology, stemming from the study of how the body responds to trauma, infection, or prolonged psychological stress. The understanding of the body's shift from an anabolic (building) state to a catabolic (breaking down) state is rooted in the discovery and study of glucocorticoids and catecholamines. It serves as a clinical marker for the severity and duration of systemic stress.

What is the Mechanism of Catabolic Stress Response?

The primary driver is the sustained release of cortisol from the adrenal cortex, which promotes gluconeogenesis and the breakdown of muscle protein and adipose tissue triglycerides. Glucagon and catecholamines further amplify this effect by increasing heart rate and systemic glucose output. Over time, this hormonal cascade leads to insulin resistance, immune suppression, and a loss of lean body mass, accelerating biological aging and impairing recovery.

Catabolic Stress Response

Meaning

The Catabolic Stress Response is a coordinated physiological reaction, primarily mediated by stress hormones, characterized by the breakdown of complex molecules into simpler ones to mobilize energy reserves. This essential survival mechanism is acutely beneficial for immediate energy demands but becomes detrimental when chronically activated, leading to muscle wasting and bone demineralization. Clinically, it represents a state of prolonged negative energy balance and tissue breakdown.

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Catabolic Stress Response

Meaning

Origin

Mechanism

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