A targeted clinical strategy aimed at reducing the systemic activity and concentration of hormones that promote the breakdown of complex molecules into simpler ones, such as proteins into amino acids. The primary focus is often on managing cortisol, the principal catabolic glucocorticoid, to mitigate its negative effects on muscle, bone, and immune function. This suppression is a key element in optimizing the anabolic-catabolic balance for health and performance.
Origin
The terminology derives from the metabolic process of “catabolism,” the destructive phase of metabolism, and the physiological concept of “hormone suppression” to achieve a desired therapeutic effect. It is a core concept in performance and longevity medicine, emphasizing the preservation of lean body mass. The understanding of cortisol’s pervasive effects solidified this clinical approach.
Mechanism
Suppression is achieved through various interventions, including pharmacological agents, specific nutrient timing, and lifestyle adjustments that reduce chronic stress inputs to the HPA axis. By lowering the catabolic signal, the body shifts towards anabolism, facilitating tissue repair, muscle preservation, and a more robust metabolic state. This mechanism helps to conserve energy reserves and protect against protein wasting.
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