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Catabolic Hormone Dominance

Meaning

Catabolic Hormone Dominance describes a physiological state where the circulating levels and biological effects of catabolic hormones, such as cortisol and glucagon, outweigh the influence of anabolic hormones like testosterone, growth hormone, and insulin. This imbalance shifts the body’s metabolic environment toward the breakdown of complex molecules, specifically protein and fat, for immediate energy use, rather than the synthesis of new tissues. Clinically, this state is associated with adverse outcomes including muscle wasting, impaired immune function, and increased visceral adiposity. It signifies a prolonged state of physiological stress that hinders tissue repair and adaptation.