Catabolic Hormone Dampening is a clinical strategy aimed at deliberately reducing the circulating levels or biological effects of hormones that promote tissue breakdown, energy mobilization, and a state of physiological stress. The primary hormone targeted is often cortisol, but it can also involve glucagon and excessive adrenaline. The goal is to shift the body’s internal balance away from catabolism and toward anabolism and recovery, thereby preserving lean body mass and improving immune function.
Origin
This concept is derived from sports endocrinology and stress physiology, where chronic, elevated catabolic signaling is recognized as detrimental to performance, recovery, and overall health. The term “dampening” implies a controlled reduction or moderation, distinguishing it from complete suppression, which would be pathologically unsound. It emphasizes optimizing the stress response rather than eliminating it entirely.
Mechanism
Dampening mechanisms involve interventions that stabilize the Hypothalamic-Pituitary-Adrenal (HPA) axis, reducing the excessive release of Corticotropin-Releasing Hormone (CRH) and Adrenocorticotropic Hormone (ACTH), which drive cortisol production. Behavioral and nutritional protocols, such as timed nutrient intake and specific stress-reducing practices, are used to modulate the frequency and amplitude of cortisol pulses. Effective dampening supports recovery by minimizing protein breakdown and preserving glycogen stores.
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