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Catabolic Dominance Reversal

Meaning

Catabolic Dominance Reversal is a critical clinical objective defined as shifting the systemic balance away from destructive, energy-releasing metabolic processes toward constructive, energy-storing, and tissue-building states. In states of chronic stress, aging, or illness, the body can enter catabolic dominance, characterized by excessive breakdown of lean tissue, particularly muscle and bone, mediated by hormones like cortisol. The reversal strategy aims to restore a favorable anabolic-to-catabolic hormone ratio, thereby promoting cellular repair, tissue regeneration, and structural integrity. This physiological shift is fundamental for achieving vitality, improving body composition, and enhancing overall longevity.