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Catabolic Control

Meaning

Catabolic control refers to the precise, hormonally-mediated regulation of catabolism, the metabolic process involving the breakdown of complex molecules into simpler ones, primarily for energy generation or recycling of cellular components. Key endocrine mediators of catabolic control include cortisol, which mobilizes glucose and fatty acids during stress, and glucagon, which promotes hepatic glycogenolysis and gluconeogenesis. Maintaining optimal catabolic control is crucial for managing body composition, ensuring adequate energy substrate availability, and preventing excessive muscle or bone tissue degradation. Dysregulation, such as chronic hypercortisolemia, can lead to adverse metabolic and structural health outcomes.