Skip to main content

Cardiovascular Safety of Testosterone

Meaning

Cardiovascular safety of testosterone refers to the rigorous clinical assessment and ongoing evaluation of the potential effects of exogenous testosterone administration on the structure and function of the heart and systemic vascular system. It is a critical consideration in Testosterone Replacement Therapy (TRT), particularly for men with pre-existing cardiovascular risk factors or established disease. The evaluation necessitates continuous monitoring for changes in hematocrit, lipid profiles, blood pressure, and the incidence of major adverse cardiovascular events (MACE). Clinicians must balance the benefits of treating symptomatic hypogonadism with the need to mitigate any potential pro-thrombotic or atherogenic risks associated with the therapy.