Describes the interconnected relationship between the body’s hormonal and metabolic systems and the functional integrity of the heart and vasculature. It is a clinical shorthand for recognizing how endocrine signaling directly influences blood pressure, lipid profiles, and endothelial function. A robust link signifies optimal hemodynamic balance and reduced cardiometabolic risk.
Origin
The understanding of this link is rooted in classical endocrinology and cardiology, particularly the discovery of how hormones like thyroid, cortisol, and sex steroids regulate cardiovascular homeostasis. It emphasizes the systemic nature of circulatory health, moving beyond a purely mechanical view of the heart. Research has increasingly focused on the role of inflammation as a mediator in this complex relationship.
Mechanism
Hormones regulate the cardiovascular system by modulating vascular tone via nitric oxide pathways, controlling fluid balance through the Renin-Angiotensin-Aldosterone System (RAAS), and influencing myocardial contractility. Dysregulation of key hormones, such as insulin resistance or estrogen deficiency, precipitates adverse changes in the endothelium and promotes atherosclerotic progression. Optimal endocrine function is a primary defense against cardiometabolic pathology.
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