What is the Origin of Cardioprotection Peptides?

The concept of cardioprotection peptides emerged primarily from the discovery and characterization of the natriuretic peptide system, originating from the heart and brain. Subsequent research within endocrinology and cardiology identified other protective peptides, including certain growth factors and vasoactive molecules. This field focuses on leveraging the body's own protective hormonal signals for therapeutic benefit.

What is the Mechanism of Cardioprotection Peptides?

These peptides operate by binding to specific G-protein coupled receptors on cardiac myocytes, endothelial cells, and renal tubules, activating intracellular signaling pathways. For instance, natriuretic peptides activate guanylate cyclase, increasing cyclic GMP, which leads to smooth muscle relaxation and diuresis. This precise mechanism helps to reduce cardiac preload and afterload, thereby protecting the heart from excessive strain and remodeling.

Cardioprotection Peptides ∞ Area

Cardioprotection Peptides

Meaning

Cardioprotection peptides are a class of endogenous signaling molecules, typically small proteins, that are integral to maintaining cardiovascular health and mitigating damage to the heart muscle and vasculature. These peptides exhibit beneficial effects such as vasodilation, natriuresis, anti-fibrotic activity, and modulation of blood pressure. Clinically, they represent a key component of the body’s intrinsic defense system against hypertension and heart failure.