What is the Origin of Cardio-Endocrine Axis?

This concept emerged from clinical observations in endocrinology and cardiology, recognizing that hormonal imbalances frequently precipitate or exacerbate cardiovascular pathology. The term "axis" denotes a functional relationship or pathway, much like the Hypothalamic-Pituitary-Adrenal (HPA) axis, emphasizing the interconnected and mutually regulatory nature of these two major organ systems. It provides a framework for understanding systemic disease processes.

What is the Mechanism of Cardio-Endocrine Axis?

Hormones like thyroid hormones, cortisol, aldosterone, and natriuretic peptides exert profound effects on cardiac contractility, vascular tone, and myocardial remodeling. For example, the Renin-Angiotensin-Aldosterone System (RAAS), a major endocrine regulator, directly influences blood pressure and fluid retention, while the heart itself secretes B-type Natriuretic Peptide (BNP) in response to volume overload, acting as a counter-regulatory hormone. The axis functions through hormonal feedback loops and receptor-mediated signaling to maintain systemic homeostasis.

Cardio-Endocrine Axis

Meaning

The Cardio-Endocrine Axis represents the intricate, bidirectional signaling system that governs the physiological interplay between the cardiovascular system and the endocrine system. This complex network involves the heart and blood vessels responding to hormones, while endocrine organs, such as the thyroid and adrenal glands, simultaneously regulate cardiovascular function, metabolism, and fluid balance. Dysfunction within this axis is central to the pathogenesis of common conditions like heart failure, hypertension, and diabetes.