Question 1

What is the Meaning of Carboxymethylcellulose (CMC)?

Accepted Answer

Carboxymethylcellulose (CMC) is a water-soluble cellulose derivative. This anionic polymer functions as a thickener, stabilizer, and binder, forming viscous solutions. It is widely employed as an excipient in pharmaceutical, cosmetic, and food products, contributing to their physical properties and stability.

Question 2

What is the Context of Carboxymethylcellulose (CMC)?

Accepted Answer

CMC is not naturally found in human physiology; rather, it is incorporated into products for human use. It serves as an inactive ingredient in oral medications, like tablets and liquid suspensions, improving consistency and patient acceptance. Its application extends to ophthalmic solutions and certain dietary supplements.

Question 3

What is the Significance of Carboxymethylcellulose (CMC)?

Accepted Answer

Clinically, CMC enhances therapeutic agent quality and delivery. It improves drug stability, ensures uniform active compound distribution, and aids medication palatability. For individuals, CMC can alleviate symptoms, as in artificial tears, or promote bowel regularity as a fiber source.

Question 4

What is the Mechanism of Carboxymethylcellulose (CMC)?

Accepted Answer

The primary action of carboxymethylcellulose involves its ability to absorb water, forming a viscous gel. This property allows it to stabilize emulsions, suspend particles, and control drug release in pharmaceuticals. In the gastrointestinal tract, it increases stool bulk and softens consistency, facilitating colonic transit physically.

Question 5

What is the Application of Carboxymethylcellulose (CMC)?

Accepted Answer

In clinical practice, CMC is utilized across numerous product categories. It acts as a binder or disintegrant in oral tablet formulations, optimizing drug release. As a suspending agent, it maintains homogeneity in liquid medications. Beyond pharmaceuticals, CMC is found in artificial tears for ocular use and as a dietary fiber.

Question 6

What is the Metric of Carboxymethylcellulose (CMC)?

Accepted Answer

Direct measurement of carboxymethylcellulose levels in biological fluids is not clinically relevant, as it is largely unabsorbed. Its efficacy is assessed indirectly by evaluating the product's performance. This includes monitoring drug stability, observing improvements in patient symptoms, and ensuring formulation quality.

Question 7

What is the Risk of Carboxymethylcellulose (CMC)?

Accepted Answer

While generally considered safe for its intended uses, CMC carries minimal risks. Ingesting substantial amounts, particularly as a fiber supplement, might induce mild gastrointestinal discomfort like bloating or cramping. Allergic reactions or hypersensitivity are exceedingly rare. Adherence to recommended dosages minimizes adverse effects.

Carboxymethylcellulose (CMC)

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

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