This clinical concept involves the strategic application of dietary and nutrient interventions to reduce the risk of oncogenesis and tumor progression. It is a proactive, evidence-based approach that utilizes specific foods, macronutrient ratios, and bioactive compounds to influence cellular pathways related to cancer development. This nutritional strategy aims to foster an internal environment that is inhospitable to malignant transformation and proliferation.
Origin
The foundation of this field stems from extensive epidemiological studies correlating specific dietary patterns with population-level cancer incidence, leading to the establishment of nutrition as a modifiable risk factor. The term combines the clinical goal of “cancer prevention” with the intervention domain of “nutrition.” Modern research has refined this into a mechanism-focused discipline, moving beyond simple correlation to identify specific chemopreventive agents in the diet.
Mechanism
The protective effect of this nutritional paradigm is mediated through several biological mechanisms, including the reduction of systemic inflammation and oxidative stress, which are precursors to cellular damage. Key nutrients can modulate hormone metabolism, such as estrogen and androgen pathways, and support detoxification processes. Furthermore, specific dietary components can directly influence the epigenome and promote cell cycle arrest or apoptosis in precancerous cells.
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