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CaMKII Misregulation

Meaning

CaMKII misregulation refers to the abnormal or dysfunctional activity of Calcium/Calmodulin-dependent protein kinase II, a crucial enzyme involved in signal transduction within cells, particularly neurons and muscle cells. This enzyme’s proper function is essential for processes like synaptic plasticity, memory formation, and the regulation of cardiac and skeletal muscle contraction. Misregulation, either through excessive or insufficient activity, disrupts cellular signaling cascades, contributing to pathologies relevant to metabolic and hormonal health.