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Calorie Restriction Mimetics

Meaning

Calorie Restriction Mimetics are pharmacological agents or specific compounds designed to replicate the beneficial metabolic and longevity-promoting effects of dietary calorie restriction without necessitating a reduction in total caloric intake. These substances aim to activate the same survival pathways and cellular stress responses triggered by a state of nutrient scarcity. The clinical goal is to leverage the anti-aging and healthspan benefits associated with restricted energy intake, such as improved insulin sensitivity and reduced oxidative stress.