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Calorie Restriction Alternatives

Meaning

Non-dietary or modified dietary strategies that are specifically designed to elicit the same favorable metabolic and longevity-promoting effects as chronic caloric restriction without requiring a persistent, severe reduction in overall energy intake. These alternatives focus on the temporal or qualitative manipulation of nutrient sensing pathways to successfully mimic the physiological fasted state. Key examples include intermittent fasting, periodic fasting-mimicking diets, and the use of pharmacological mimetics.