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Caloric Restriction Science

Meaning

Caloric Restriction Science is the body of research investigating the physiological and molecular effects of reducing overall caloric intake without inducing malnutrition, specifically focusing on its impact on healthspan and longevity. This scientific domain explores how a sustained, moderate energy deficit influences metabolic flexibility, cellular repair mechanisms, and endocrine signaling. Clinical application involves translating these findings into practical dietary protocols, such as intermittent fasting or time-restricted feeding, to leverage the longevity benefits in humans. The central hypothesis posits that a reduced energy flux activates protective stress responses.