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Caloric Restriction Gene Health

Meaning

Caloric Restriction Gene Health refers to the beneficial changes in gene expression and epigenetic programming induced by a sustained reduction in calorie intake without malnutrition. This dietary intervention activates specific longevity-associated genes, leading to enhanced cellular repair, improved metabolic efficiency, and reduced systemic inflammation. The concept is central to understanding how nutritional stress can positively modulate the genome’s activity to promote healthspan and slow biological aging. Clinically, it involves carefully managing energy intake to harness these protective genetic responses.