What is the Origin of Calcium Homeostasis?

The concept derives from the Greek 'homoios' (similar) and 'stasis' (standing still), applied to the element calcium, derived from the Latin 'calx' (lime). It describes the dynamic equilibrium maintained by several organ systems working in concert. This regulation is a classic example of endocrine control in human physiology.

What is the Mechanism of Calcium Homeostasis?

The primary regulators are Parathyroid Hormone (PTH), which increases serum calcium, and calcitriol (active Vitamin D), which promotes intestinal absorption and bone resorption. Calcitonin acts as a minor counter-regulatory hormone attempting to lower calcium levels following meals or high bone turnover. These hormones act on bone, kidney, and gut tissues to maintain the required electrochemical gradients.

Calcium Homeostasis

Meaning

Calcium homeostasis represents the highly regulated physiological process ensuring stable concentrations of ionized calcium in the extracellular fluid, which is vital for neuromuscular excitability and cellular signaling. Deviation from this narrow range can precipitate serious clinical manifestations affecting cardiac and skeletal function. This balance is intricately tied to endocrine feedback loops.