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CACNA1D

Meaning

CACNA1D is the official gene symbol for the alpha-1D subunit of a voltage-dependent L-type calcium channel, which plays a critical role in regulating intracellular calcium signaling in endocrine cells and excitable tissues. In the context of hormonal health, gain-of-function mutations in this specific gene have been identified as a significant cause of primary aldosteronism, a form of hypertension. This gene’s product is essential for the electrical excitability and subsequent hormone secretion of cells within the adrenal cortex. Understanding the function of CACNA1D is crucial for diagnosing and potentially targeting specific forms of endocrine hypertension.