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C-Terminal Telopeptide

Meaning

C-Terminal Telopeptide, often abbreviated as CTX, is a specific protein fragment released into circulation during the breakdown of Type I collagen, the most abundant protein in bone and connective tissue. It serves as a highly reliable biochemical marker for bone resorption, providing a quantitative measure of osteoclast activity. Clinically, CTX levels are integral for monitoring the efficacy of anti-resorptive therapies, such as bisphosphonates, and assessing fracture risk.