What is the Origin of C-Reactive Protein (hs-CRP)?

The protein was first identified in 1930, named for its ability to react with the C-polysaccharide of Streptococcus pneumoniae. Clinically, the shift to the high-sensitivity assay emerged from the recognition that even modestly elevated levels, far below those seen in acute infection, carry prognostic significance for chronic diseases. This development transformed CRP from a marker of acute infection to a powerful predictor of underlying systemic stress.

What is the Mechanism of C-Reactive Protein (hs-CRP)?

As an inflammatory marker, CRP production is primarily stimulated by pro-inflammatory cytokines, notably interleukin-6 (IL-6), which are released by adipose tissue and immune cells in response to tissue injury or chronic stress. High circulating levels of hs-CRP can interfere with endothelial function and contribute to insulin resistance, creating a pro-inflammatory environment that negatively impacts the entire endocrine system. Therefore, monitoring this protein offers a window into the silent inflammatory burden that often underlies hormonal dysregulation.

C-Reactive Protein (hs-CRP) ∞ Area

C-Reactive Protein (hs-CRP)

Meaning

C-Reactive Protein is an acute-phase reactant synthesized by the liver, functioning as a critical, non-specific biomarker of systemic inflammation within the body. The high-sensitivity assay, designated as hs-CRP, is specifically employed in clinical practice to detect low-grade, chronic inflammation, which is often subclinical yet highly relevant to long-term health risk. Elevated hs-CRP levels are frequently correlated with chronic conditions that impact hormonal balance, cardiovascular health, and metabolic function.