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C-17 Alpha-Alkylated Steroids

Meaning

C-17 Alpha-Alkylated Steroids represent a specific class of synthetic anabolic-androgenic steroids (AAS) modified by the addition of an alkyl group, typically a methyl group, at the 17th carbon position of the steroid nucleus. This structural modification is a pharmacological strategy employed to enhance oral bioavailability and prevent rapid hepatic metabolism. Clinically, this modification is associated with increased hepatotoxicity compared to non-alkylated steroid forms, necessitating careful clinical monitoring.