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Butyrate Signaling

Meaning

Butyrate Signaling refers to the crucial biochemical communication pathway mediated by butyrate, a short-chain fatty acid (SCFA) produced by the gut microbiota through the fermentation of dietary fiber. This signaling molecule acts as a primary energy source for colonocytes, maintaining the integrity of the intestinal barrier, which is essential for preventing systemic inflammation. Beyond the gut, butyrate engages in extensive cross-talk with the immune system and the central nervous system, influencing gene expression and neuroendocrine function throughout the body. Its presence is a key biomarker of a healthy, functional gut microbiome.