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Burnout Pathophysiology

Meaning

Burnout Pathophysiology describes the specific biological and physiological mechanisms underlying the clinical syndrome of burnout, which is characterized by emotional exhaustion, cynicism, and reduced professional efficacy. This condition is not merely psychological but involves measurable dysregulation of the neuroendocrine and immune systems, particularly chronic HPA axis dysfunction. Clinically, we observe a critical shift from an acute, adaptive stress response to a chronic, maladaptive state of allostatic overload. This framework allows for targeted biological interventions alongside necessary psychological support.