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Brexanolone

Meaning

A synthetic neuroactive steroid and a pharmacological analogue of allopregnanolone, which is a naturally occurring metabolite of the hormone progesterone. Brexanolone is clinically significant as the first medication specifically approved for the treatment of postpartum depression, reflecting a targeted approach to neuroendocrine-related mood disorders. It represents a direct intervention in the central nervous system’s response to hormonal fluctuations following childbirth.